"Activated"
Currently uploaded 7TM coordinates are shown in red (X-ray entries only).
G protein-coupled receptors (activated)
(partial, biased, allosteric) agonist bound or ligand free
The term "activated" does not necessarily mean that the structures differ from the "inactivated".
The count for "mutated" in the remarks is of 200 residue 7TM region only.
Abbreviations
reso: resolution (from PDB)
Ab: antibody bound
Nb: nanobody bound
T4L: ICL3 replaced with T4 lysozyme
T4L-N: T4 lysozyme N-terminally fuzed
cyt: mutated apocytochrome b562 N-terminally fuzed
cyt-ICL3: ICL3 replaced with mutated apocytochrome b562
flabo: ICL3 replaced with flabodoxin
GlgA: ICL3 replaced with catalytic domain of glycogen synthase GlgA
rub: ICL3 replaced with rubredoxin
trxA: thioredoxin N-terminally fuzed
xfel: x-ray free electron laser
| receptor | PDB | 7TM | reso | ligand | remarks |
|---|---|---|---|---|---|
| rhodopsin | 2G87 | 200 (A) | 2.60 | all-trans-retinal | bovine, batho-state |
| 200 (B) | 2.60 | all-trans-retinal | bovine, batho-state | ||
| 2HPY | 200 (A) | 2.80 | all-trans-retinal | bovine, lumi-state | |
| 200 (B) | 2.80 | all-trans-retinal | bovine, lumi-state | ||
| 2I37 | 199 (A) | 4.15 | invisible | bovine | |
| 200 (B) | 4.15 | invisible | bovine | ||
| 195 (C) | 4.15 | invisible | bovine | ||
| 3CAP | 200 (A) | 2.90 | none | bovine | |
| 200 (B) | 2.90 | none | bovine | ||
| 3DQB | 200 (A) | 3.20 | none | bovine, Gt-peptide | |
| 3PQR | 200 (A) | 2.85 | all-trans-retinal | bovine, Gt-peptide | |
| 3PXO | 200 (A) | 3.00 | all-trans-retinal | bovine | |
| 4J4Q | 200 (A) | 2.65 | octylglucoside | bovine, Gt-peptide | |
| 2X72 | 200 (A) | 3.00 | all-trans-retinal | bovine, 1 mutated, Gt-peptide | |
| 4A4M | 200 (A) | 3.30 | all-trans-retinal | bovine, 1 mutated, Gt-peptide | |
| 4BEY | 200 (A) | 2.90 | none | bovine, 1 mutated, Gt-peptide | |
| 4BEZ | 200 (A) | 3.30 | none | bovine, 1 mutated(2.57) | |
| 4PXF | 200 (A) | 2.75 | octylglucoside | bovine, arr-peptide | |
| 4ZWJ | 200 (A) | 3.30 | none | bovine, arr, xfel | |
| 200 (B) | 3.30 | none | bovine, arr, xfel | ||
| 200 (C) | 3.30 | none | bovine, arr, xfel | ||
| 200 (D) | 3.30 | none | bovine, arr, xfel | ||
| 4X1H | 200 (A) | 2.29 | nonylglucoside | bovine, Gt-peptide | |
| 5DYS | 200 (A) | 2.30 | all-trans-retinal | bovine, 1 mutated(2.61) | |
| 5EN0 | 200 (A) | 2.81 | all-trans-retinal | bovine,1 mutated,Gt-peptide | |
| 5TE3 | 200 (A) | 2.70 | octylglucoside | bovine | |
| 5W0P | 200 (A) | 3.01 | none | bovine,T4L-N,arr,xfel,14mut | |
| 200 (B) | 3.01 | none | bovine,T4L-N,arr,xfel,14mut | ||
| 200 (C) | 3.01 | none | bovine,T4L-N,arr,xfel,14mut | ||
| 200 (D) | 3.01 | none | bovine,T4L-N,arr,xfel,14mut | ||
| 5WKT | 200 (A) | 3.20 | octylglucoside | bovine,Gt-peptide | |
| 6FK6 | 200 (A) | 2.36 | RS01 | bovine | |
| 6FK7 | 200 (A) | 2.62 | RS06 | bovine | |
| 6FK8 | 200 (A) | 2.87 | RS08 | bovine | |
| 6FK9 | 200 (A) | 2.63 | RS09 | bovine | |
| 6FKA | 200 (A) | 2.70 | RS11 | bovine | |
| 6FKB | 200 (A) | 3.03 | RS13 | bovine | |
| 6FKC | 200 (A) | 2.46 | RS15 | bovine | |
| 6FKD | 200 (A) | 2.49 | RS16 | bovine | |
| 6FUF | 200 (A) | 3.12 | all-trans-retinal | bovine, mini-Go, 6.40 | |
| 3AYM | 200 (A) | 2.80 | all-trans-retinal | squid, batho-state | |
| 200 (B) | 2.80 | all-trans-retinal | squid, batho-state | ||
| 4WW3 | 200 (A) | 2.80 | all-trans-retinal | squid, lumi-state | |
| 200 (B) | 2.80 | all-trans-retinal | squid, lumi-state | ||
| beta2 adrenergic | 3P0G | 200 (A) | 3.50 | BI-167107 | human, Nb, T4L |
| 3PDS | 200 (A) | 3.50 | FAUC50 | human, 2.64, T4L | |
| 3SN6 | 200 (A) | 3.20 | BI-167107 | human, 2.67, Gs, Nb, T4L-N | |
| 4LDE | 200 (A) | 2.79 | BI-167107 | human, 2.67, Nb, T4L-N | |
| 4LDL | 200 (A) | 3.10 | XQC | human, 2.67, Nb, T4L-N | |
| 4LDO | 200 (A) | 3.20 | adrenaline | human, 2.67, Nb, T4L-N | |
| 4QKX | 200 (A) | 3.30 | 35V | human, 2 mutated, Nb, T4L-N | |
| 6E67 | 200 (A) | 3.70 | BI-167107 | human,3mutated,T4L-Gs-peptide | |
| 200 (B) | 3.70 | BI-167107 | human,3mutated,T4L-Gs-peptide | ||
| 6MXT | 200 (A) | 2.96 | salmeterol | human, 2.67, Nb, T4L-N | |
| 6N48 | 200 (A) | 3.20 | BI-167107 | human, 2.67, Nb, T4L-N | |
| beta1 adrenergic | 2Y00 | 200 (A) | 2.50 | dobutamin | turkey, 6 mutated |
| 200 (B) | 2.50 | dobutamin | turkey, 6 mutated | ||
| 2Y01 | 200 (A) | 2.60 | dobutamin | turkey, 6 mutated | |
| 200 (B) | 2.60 | dobutamin | turkey, 6 mutated | ||
| 2Y02 | 200 (A) | 2.60 | carmoterol | turkey, 6 mutated | |
| 200 (B) | 2.60 | carmoterol | turkey, 6 mutated | ||
| 2Y03 | 200 (A) | 2.85 | isoprenaline | turkey, 6 mutated | |
| 200 (B) | 2.85 | isoprenaline | turkey, 6 mutated | ||
| 2Y04 | 200 (A) | 3.05 | salbutamol | turkey, 6 mutated | |
| 200 (B) | 3.05 | salbutamol | turkey, 6 mutated | ||
| 4AMI | 200 (A) | 3.20 | bucindolol | turkey, 6 mutated | |
| 200 (B) | 3.20 | bucindolol | turkey, 6 mutated | ||
| 6H7J | 200 (A) | 2.80 | isoprenaline | turkey, 6 mutated, trxA, Nb | |
| 200 (B) | 2.80 | isoprenaline | turkey, 6 mutated, trxA, Nb | ||
| 6H7L | 200 (A) | 2.70 | dobutamin | turkey, 6 mutated, trxA, Nb | |
| 200 (B) | 2.70 | dobutamin | turkey, 6 mutated, trxA, Nb | ||
| 6H7M | 200 (A) | 2.76 | salbutamol | turkey, 6 mutated, trxA, Nb | |
| 200 (B) | 2.76 | salbutamol | turkey, 6 mutated, trxA, Nb | ||
| 6H7O | 200 (A) | 2.80 | cyanopindolol | turkey, 6 mutated, trxA, Nb | |
| 200 (B) | 2.80 | cyanopindolol | turkey, 6 mutated, trxA, Nb | ||
| adenosine A2A | 3QAK | 200 (A) | 2.71 | UK-432097 | human, T4L |
| 2YDO | 200 (A) | 3.00 | adenosine | human, 4 mutated | |
| 2YDV | 200 (A) | 2.60 | NECA | human, 4 mutated | |
| 4UG2 | 200 (A) | 2.60 | CGS21680 | human, 4 mutated | |
| 200 (B) | 2.60 | CGS21680 | human, 4 mutated | ||
| 4UHR | 200 (A) | 2.60 | CGS21680 | human, 4 mutated | |
| 5G53 | 200 (A) | 3.40 | NECA | human, Gs mimic | |
| 200 (B) | 3.40 | NECA | human, Gs mimic | ||
| 5WF5 | 200 (A) | 2.60 | UK432097 | human, T4L, 2.50 | |
| 5WF6 | 200 (A) | 2.90 | UK432097 | human, T4L, 3.39 | |
| neurotensin 1 | 4GRV | 200 (A) | 2.80 | hexapeptide | rat, 5 mutated, T4L |
| 3ZEV | 200 (A) | 2.80 | hexapeptide | rat, 9 mutated | |
| 199 (B) | 2.80 | hexapeptide | rat, 9 mutated | ||
| 4BUO | 200 (A) | 2.75 | hexapeptide | rat, 9 mutated | |
| 200 (B) | 2.75 | hexapeptide | rat, 9 mutated | ||
| 4BV0 | 200 (A) | 3.10 | hexapeptide | rat, 24 mutated | |
| 200 (B) | 3.10 | hexapeptide | rat, 24 mutated | ||
| 4BWB | 199 (A) | 3.57 | hexapeptide | rat, 23 mutated | |
| 200 (B) | 3.57 | hexapeptide | rat, 23 mutated | ||
| 4XES | 200 (A) | 2.60 | hexapeptide | rat, 3 mutated | |
| 4XEE | 200 (A) | 2.90 | hexapeptide | rat, 2 mutated | |
| 5T04 | 200 (A) | 3.30 | hexapeptide | rat, 3 mutated | |
| serotonin HT1B | 4IAQ | 200 (A) | 2.80 | dihydroergotamine | human, cyt-ICL3, 3.41 |
| 4IAR | 200 (A) | 2.70 | ergotamine | human, cyt-ICL3, 3.41 | |
| 7C61 | 198 (A) | 3.00 | ergotamine | human, cyt-ICL3, 3.41 | |
| serotonin HT2A | 6WGT | 200 (A) | 3.40 | 7LD | human, cyt-ICL3, 5.51/7.44 |
| 200 (B) | 3.40 | 7LD | human, cyt-ICL3, 5.51/7.44 | ||
| 200 (C) | 3.40 | 7LD | human, cyt-ICL3, 5.51/7.44 | ||
| serotonin HT2B | 4IB4 | 200 (A) | 2.70 | ergotamine | human, cyt-ICL3, 3.41 |
| 4NC3 | 200 (A) | 2.80 | ergotamine | human, cyt-ICL3, 3.41, xfel | |
| 5TVN | 200 (A) | 2.90 | LSD | human, cyt-ICL3, 3.41 | |
| 5TUD | 200 (A) | 3.00 | ergotamine | human, Ab, 3.41 | |
| 200 (D) | 3.00 | ergotamine | human, Ab, 3.41 | ||
| 6DS0 | 200 (A) | 3.19 | LY266097 | human, cyt-ICL3 | |
| 6DRX | 200 (A) | 3.10 | lisuride | human, cyt-ICL3 | |
| 6DRY | 200 (A) | 2.92 | methylergonovine | human, cyt-ICL3 | |
| 6DRZ | 200 (A) | 3.10 | methysergide | human, cyt-ICL3, 5.46 | |
| serotonin HT2C | 6BQG | 200 (A) | 3.00 | ergotamine | human,cyt-ICL3,7.45 |
| melatonin MT1 | 6ME2 | 200 (A) | 2.80 | ramelteon | human, GlgA, 7mutated, xfel |
| 6ME3 | 200 (A) | 2.90 | 2-phenylmelatonin | human, GlgA, 7mutated, xfel | |
| 6ME4 | 200 (A) | 3.20 | 2-iodomelatonin | human, GlgA, 7mutated, xfel | |
| 6ME5 | 200 (A) | 3.20 | agomelatine | human, GlgA, 7mutated, xfel | |
| 6PS8 | 200 (A) | 3.30 | 2-phenylmelatonin | human, GlgA, 7mutated, xfel | |
| melatonin MT2 | 6ME6 | 200 (A) | 2.80 | 2-phenylmelatonin | human, cyt, rub, 6mutated, xfel |
| 200 (B) | 2.80 | 2-phenylmelatonin | human, cyt, rub, 6mutated, xfel | ||
| 6ME7 | 200 (A) | 3.20 | 2-phenylmelatonin | human, cyt, rub, 7mutated, xfel | |
| 200 (B) | 3.20 | 2-phenylmelatonin | human, cyt, rub, 7mutated, xfel | ||
| 6ME8 | 200 (A) | 3.10 | 2-phenylmelatonin | human, cyt, rub, 5mutated, xfel | |
| 200 (B) | 3.10 | 2-phenylmelatonin | human, cyt, rub, 5mutated, xfel | ||
| 6ME9 | 200 (A) | 3.30 | ramelteon | human, cyt, rub, 6mutated, xfel | |
| 200 (B) | 3.30 | ramelteon | human, cyt, rub, 6mutated, xfel | ||
| M2 muscarinic | 4MQS | 200 (A) | 3.50 | iperoxo | human,Nb |
| 4MQT | 200 (A) | 3.70 | iperoxo | human,Nb,LY2119620 | |
| GPR40 | 4PHU | 200 (A) | 2.30 | TAK-875 | human,4 mutated,T4L |
| 5TZR | 200 (A) | 2.20 | MK6 | human,4 mutated,T4L | |
| 5TZY | 200 (A) | 3.22 | MK6,7OS | human,3 mutated,T4L | |
| 5KW2 | 200 (A) | 2.76 | compound 1 | human,4 mutated,T4L | |
| GPR52 | 6LI0 | 198 (A) | 2.20 | c17 | human, 5 mutated, flabo |
| 6LI1 | 198 (A) | 2.90 | none | human, 5 mutated, flabo | |
| 6LI2 | 196 (A) | 2.80 | none | human, 5 mutated, rub | |
| mu opioid | 5C1M | 200 (A) | 2.10 | BU72 | mouse, Nb |
| kappa opioid | 6B73 | 200 (A) | 3.10 | MP1104 | human, Nb |
| 200 (B) | 3.10 | MP1104 | human, Nb | ||
| delta opioid | 6PT2 | 200 (A) | 2.80 | KGCHM07 | human, cyt, 8 mutated |
| 200 (B) | 2.80 | KGCHM07 | human, cyt, 8 mutated | ||
| 6PT3 | 200 (A) | 3.30 | DPI-287 | human, cyt, 8 mutated | |
| 200 (B) | 3.30 | DPI-287 | human, cyt, 8 mutated | ||
| endothelin ETB | 5GLH | 198 (A) | 2.80 | ET-1 | human, T4L, 4 mutated |
| 6IGK | 200 (A) | 2.00 | Endothelin-3 | human, T4L, 4 mutated | |
| 6IGL | 200 (A) | 2.70 | IRL1620 | human, T4L, 4 mutated | |
| 6LRY | 200 (A) | 3.00 | sarafotoxin S6b | human, T4L, 4 mutated | |
| P2Y12 | 4PXZ | 200 (A) | 2.50 | 2MeSADP | human, cyt-ICL3 |
| 4PY0 | 199 (A) | 3.10 | 2MeSATP | human, cyt-ICL3 | |
| viral US28 | 4XT1 | 199 (A) | 2.89 | CX3CL1 | Cytomegalovirus, Nb |
| 4XT3 | 200 (A) | 3.80 | CX3CL1 | Cytomegalovirus | |
| 5WB1 | 200 (A) | 3.51 | none | Cytomegalovirus, Nb | |
| 5WB2 | 200 (A) | 3.50 | CX3CL1.35 | Cytomegalovirus, Nb | |
| AT1 angiotensin | 6DO1 | 200 (A) | 2.90 | none | human, Nb |
| 200 (B) | 2.90 | none | human, Nb | ||
| 6OS0 | 200 (A) | 2.90 | angiotensin II | human, cyt-ICL, Nb | |
| 6OS1 | 200 (A) | 2.79 | TRV023 | human, cyt-ICL, Nb | |
| 6OS2 | 200 (A) | 2.70 | TRV026 | human, cyt-ICL, Nb | |
| AT2 angiotensin | 5UNF | 200 (A) | 2.80 | 8ES | human, cyt, xfel, P21 |
| 199 (B) | 2.80 | 8ES | human, cyt, xfel, P21 | ||
| 5UNG | 200 (B) | 2.80 | 8ES | human, cyt, xfel, P21221 | |
| 5UNH | 197 (A) | 2.90 | 8EM | human, cyt, xfel | |
| 196 (B) | 2.90 | 8EM | human, cyt, xfel | ||
| 5XJM | 200 (A) | 3.20 | peptide | human, cyt-ICL3, Fab | |
| 6JOD | 200 (A) | 3.20 | peptide | human, cyt-ICL3, Fab | |
| 7C6A | 200 (A) | 3.40 | peptide | human, cyt-ICL3, 2.53/3.41 | |
| Apelin | 5VBL | 200 (B) | 2.60 | 17aa peptide | human,2 mutated,rub |
| 6KNM | 200 (A) | 3.20 | none | human,2 mutated,rub,Fab | |
| CB1 cannabinoid | 5XR8 | 200 (A) | 2.95 | AM841 | human, flavo |
| 5XRA | 200 (A) | 2.80 | AM11542 | human, flavo | |
| CB2 cannabinoid | 6KPC | 200 (A) | 3.20 | 8D0 | human, T4L, 5 mutated |
| formyl peptide FPR2 | 6LW5 | 200 (A) | 2.80 | WKYMVm | human, cyt, 5.48 |
| Prostaglandin E2 | 6AK3 | 200 (A) | 2.90 | prostaglandin E2 | human, 3 mutated |
| 200 (B) | 2.90 | prostaglandin E2 | human, 3 mutated | ||
| 6M9T | 200 (B) | 2.50 | misoprostol-FA | human, T4L, 6.42 | |
| GLP1R | 5NX2 | 200 (A) | 3.70 | peptide | human, >13 mutations |
| PTH1R | 6FJ3 | 199 (A) | 2.50 | peptide | human, GlgA, 9 mutations |
| smoothened | 4QIN | 200 (A) | 2.60 | SAG1.5 | human, cyt-ICL3 |
| 6D32 | 200 (A) | 3.75 | cyclopamine | xenopus,cyt-ICL3,3 mutated | |
| 6D35 | 200 (A) | 3.90 | cholesterol | xenopus,cyt-ICL3,3 mutated | |
| 6O3C | 200 (A) | 2.80 | SAG21k | mouse, Nb |
