"Inactivated"

Currently uploaded 7TM coordinates are shown in red (X-ray entries only).

G Protein-Coupled Receptors (inactivated)

antagonist or inverse agonist bound or ligand free

The count for "mutated" in the remarks is of 200 residue 7TM region only.

Abbreviations
reso: resolution (from PDB)
Ab: antibody bound
T4L: ICL3 replaced with T4 lysozyme
T4L-N: T4 lysozyme N-terminally fuzed
T4L-ICL2: ICL2 replaced with T4 lysozyme
cyt: N-term replaced with mutated apocytochrome b562
cyt-ICL3: ICL3 replaced with mutated apocytochrome b562
rub: ICL3 replaced with rubredoxin
flabo: ICL3 replaced with flabodoxin
GlgA: ICL3 replaced with catalytic domain of glycogen synthase GlgA
NanA: ICL3 replaced with sialidase
xfel: x-ray free electron laser
IMIS: in meso in situ
ortho: orthosteric ligand

receptorPDB7TMresoligandremarks
rhodopsin1GZM200 (A)2.6511-cis-retinalbovine
200 (B)2.6511-cis-retinalbovine
1U19200 (A)2.2011-cis-retinalbovine
200 (B)2.2011-cis-retinalbovine
2I35200 (A)3.8011-cis-retinalbovine
2I36200 (A)4.1011-cis-retinalbovine
196 (B)4.1011-cis-retinalbovine
200 (C)4.1011-cis-retinalbovine
2J4Y200 (A)3.4011-cis-retinalbovine
200 (B)3.4011-cis-retinalbovine
2PED200 (A)2.959-cis-retinalbovine
200 (B)2.959-cis-retinalbovine
5TE5200 (A)4.01locked retinalbovine
2Z73200 (A)2.5011-cis-retinalsquid
200 (B)2.5011-cis-retinalsquid
2ZIY200 (A)3.7011-cis-retinalsquid
3AYN200 (A)2.709-cis-retinalsquid
200 (B)2.709-cis-retinalsquid
6I9K200 (A)2.159-cis-retinalspider
beta2 adreno2RH1200 (A)2.40carazorolhuman, T4L
2R4R161 (A)3.40invisiblehuman, Ab
2R4S161 (A)3.40invisiblehuman, Ab
3D4S200 (A)2.80timololhuman, 1 mutated(3.41), T4L
3KJ6167 (A)3.40invisiblehuman, Ab, methylated
3NY8200 (A)2.84ICI 118551human, 1 mutated(3.41), T4L
3NY9200 (A)2.84JSZhuman, 1 mutated(3.41), T4L
3NYA200 (A)3.16alprenololhuman, 1 mutated(3.41), T4L
4GBR200 (A)3.99carazorolhuman, 1 mutated(2.67), T4L-N
5D5A200 (A)2.48carazorolhuman, T4L, IMIS
5D5B200 (A)3.80carazorolhuman, T4L
5D6L200 (A)3.20carazorolhuman, T4L
5JQH200 (A)3.20carazorolhuman,2.67,T4L-N,Nb
200 (B)3.20carazorolhuman,2.67,T4L-N,Nb
5X7D200 (A)2.70carazorolhuman,T4L,+Cmpd-15PA
6PRZ200 (A)2.80Alprenololhuman, T4L, xfel, 3.41
6PS0200 (A)3.40carazorolhuman, T4L, xfel, 3.41
6PS1200 (A)3.20Timololhuman, T4L, xfel, 3.41
6PS2200 (A)2.40Alprenololhuman, T4L, xfel, 3.41
6PS3200 (A)2.50Carvedilolhuman, T4L, xfel, 3.41
6PS4200 (A)2.60ICI-118551human, T4L, xfel, 3.41
6PS5200 (A)2.90Propranololhuman, T4L, xfel, 3.41
6PS6200 (A)2.70Timololhuman, T4L, xfel, 3.41
beta1 adreno2VT4200 (A)2.70cyanopindololturkey,6 mutated,TM1 bent
200 (B)2.70cyanopindololturkey,6 mutated
200 (C)2.70cyanopindololturkey,6 mutated
200 (D)2.70cyanopindololturkey,6 mutated,TM1 bent
2YCW200 (A)3.00carazorolturkey,6 mutated,TM6 bent
200 (B)3.00carazorolturkey,6 mutated
2YCY200 (A)3.15cyanopindololturkey,6 mutated,TM1 bent
200 (B)3.15cyanopindololturkey,6 mutated
2YCX200 (A)3.25cyanopindololturkey,6 mutated,TM6 bent
200 (B)3.25cyanopindololturkey,6 mutated,TM6 bent
2YCZ200 (A)3.65iodocyanopindololturkey,6 mutated
200 (B)3.65iodocyanopindololturkey,6 mutated,TM6 bent
4AMJ200 (A)2.30carvedilolturkey,6 mutated
200 (B)2.30carvedilolturkey,6 mutated
4GPO200 (A)3.50noneturkey,6 mutated
200 (B)3.50noneturkey,6 mutated
4BVN200 (A)2.10cyanopindololturkey,9 mutated
3ZPQ200 (A)2.80indole19turkey,6 mutated
200 (B)2.80indole19turkey,6 mutated
3ZPR200 (A)2.70quinoline20turkey,6 mutated
200 (B)2.70quinoline20turkey,6 mutated
5A8E200 (A)2.407-Me-cyanopindololturkey,9 mutated
alpha 2A adreno6KUX200 (A)2.70RS79948human, cyt-ICL3, 2 mutated
6KUY200 (A)3.20REShuman, cyt-ICL3, 3 mutated
alpha 2C adreno6KUW200 (A)2.80RS79948human, GlgA, 3 mutated
200 (B)2.80RS79948human, GlgA, 3 mutated
adenosine A2A3EML200 (A)2.60ZM241385human, T4L
3PWH200 (A)3.30ZM241385human, 8 mutated
3REY200 (A)3.31XAChuman, 8 mutated
3RFM200 (A)3.60caffeinehuman, 8 mutated
3VG9200 (A)2.70ZM241385human, Ab
3VGA200 (A)3.10ZM241385human, Ab
3UZA200 (A)3.27compound 4Ghuman, 8 mutated
3UZC200 (A)3.34compound 4Ehuman, 8 mutated
4EIY200 (A)1.80ZM241385human, cyt-ICL3
5IU4200 (A)1.72ZM241385human,cyt-ICL3,8 mutated
5IU7200 (A)1.90compound 12chuman,cyt-ICL3,8 mutated
5IU8200 (A)2.00compound 12fhuman,cyt-ICL3,8 mutated
5IUA200 (A)2.20compound 12bhuman,cyt-ICL3,8 mutated
5IUB200 (A)2.10compound 12xhuman,cyt-ICL3,8 mutated
5JTB200 (A)2.80ZM241385human,cyt-ICL3,I-sad
5MZJ200 (A)2.00theophyllinehuman,cyt-ICL3,8 mutated
5MZP200 (A)2.10caffeinehuman,cyt-ICL3,8 mutated
5N2R200 (A)2.80PSB36human,cyt-ICL3,8 mutated
5N2S200 (A)3.30PSB36human,cyt,6 mutated
5NLX200 (A)2.14ZM241385human,cyt-ICL3,8 mutated,xfel
5NM2200 (A)1.95ZM241385human,cyt-ICL3,8 mutated
5NM4200 (A)1.70ZM241385human,cyt-ICL3,8 mutated,xfel
5OLG200 (A)1.87ZM241385human,cyt-ICL3,8 mutated
5OLH200 (A)2.60Vipadenanthuman,cyt-ICL3,8 mutated
5OLO200 (A)3.10Tozadenanthuman,cyt-ICL3,8 mutated
5OLV200 (A)2.00LUAA47070human,cyt-ICL3,8 mutated
5OLZ200 (A)1.90Compound 4ehuman,cyt-ICL3,8 mutated
5OM1200 (A)2.10Compound 4ehuman,cyt-ICL3,8 mutated
5OM4200 (A)2.00Compound 4ehuman,cyt-ICL3,8 mutated
5UIG200 (A)3.508D1human,cyt-ICL3
5UVI200 (A)3.20ZM241385human,cyt-ICL3,xfel
5VRA200 (A)2.35ZM241385human,cyt-ICL3,in situ
6AQF200 (A)2.51ZM241385human,cyt-ICL3
6GT3200 (A)2.00AZD4635human,cyt-ICL3,8 mutated
6MH8200 (A)4.20ZM241385human,cyt-ICL3,xfel
6PS7200 (A)1.85ZM241385human,cyt-ICL3,xfel
6JZH200 (A)2.25ZM241385human,cyt-ICL3,xfel
6S0L200 (A)2.65ZM241385human,cyt-ICL3,xfel,8mutated
6S0Q200 (A)2.65ZM241385human,cyt-ICL3,xfel,8mutated
6ZDR200 (A)1.92Chromone 4dhuman,cyt-ICL3,8mutated
6ZDV200 (A)2.13Chromone 5dhuman,cyt-ICL3,8mutated
6WQA200 (A)2.00ZM241385human,cyt-ICL3,xfel
6LPJ200 (A)1.80ZM241385human,cyt-ICL3,xfel,277K
6LPK200 (A)1.80ZM241385human,cyt-ICL3,xfel,293K
6LPL200 (A)2.00ZM241385human,cyt-ICL3,xfel,100K
adenosine A15N2S200 (A)3.30PSB36human,cyt,6 mutated
5UEN200 (A)3.20DU172human,cyt-ICL3
200 (B)3.20DU172human,cyt-ICL3
CXCR2 chemokine6LFL200 (A)3.20EBXhuman, GlgA, 3 mutated
CXCR4 chemokine3ODU200 (A)2.50It1thuman, T4L
200 (B)2.50It1thuman, T4L
3OE8200 (A)3.10It1thuman, T4L
200 (B)3.10It1thuman, T4L
200 (C)3.10It1thuman, T4L
3OE9196 (A)3.10It1thuman, T4L
196 (B)3.10It1thuman, T4L
3OE6198 (A)3.20It1thuman, T4L
3OE0199 (A)2.90CVX15 peptidehuman, T4L
4RWS199 (A)3.10vMIP-IIhuman,1 mutated(6.36), T4L
CCR2 chemokine5T1A200 (A)2.81BMS-681human,rub,+ortho,8 mutated
6GPS200 (A)3.30MK-0812human, rub, 6.33
6GPX197 (A)2.70MK-0812human, rub, 6.33
196 (B)2.70MK-0812human, rub, 6.33
CCR5 chemokine4MBS200 (A)2.70maravirochuman,rub,4.60,6.33
200 (B)2.70maravirochuman,rub,4.60,6.33
5UIW200 (A)2.205P7-CCL5human,rub,4.60,6.33
6AKX200 (A)2.80compound 21human,rub,4.60,6.33
200 (B)2.80compound 21human,rub,4.60,6.33
6AKY200 (A)2.80compound 34human,rub,4.60,6.33
CCR7 chemokine6QZH198 (A)2.10Cmp2105human, NanA, 3.41
CCR9 chemokine5LWE196 (A)2.80vercirnon(ic side)human,5 mutated
197 (B)2.80vercirnon(ic side)human,5 mutated
C5a chemotactic5O9H200 (A)2.70NDT9513727human, 4 mutated
200 (B)2.70NDT9513727human, 4 mutated
6C1Q200 (B)2.90PMX53human,cyt,+NDT9513727
6C1R200 (B)2.20PMX53human,cyt,+NDT9513727
dopamine D26CM4200 (A)2.87risperidonehuman, T4L, 3 mutated
6LUQ200 (A)3.10haloperidolhuman, T4L, 3 mutated
dopamine D33PBL200 (A)2.89eticlopridehuman, T4L
200 (B)2.89eticlopridehuman, T4L
dopamine D45WIU200 (A)1.96nemonapridehuman, cyt-ICL3
5WIV200 (A)2.14nemonapridehuman, cyt-ICL3
6IQL200 (A)3.50L745870human, cyt-ICL3, 3 mutated
200 (B)3.50L745870human, cyt-ICL3, 3 mutated
histamine H13RZE200 (A)3.10doxepinhuman, T4L
M1 muscarinic5CXV200 (A)2.70tiotropiumhuman, T4L
6WJC200 (A)2.55atropinhuman, 3.39, Toxin7
M2 muscarinic3UON200 (A)3.00QNBhuman, T4L
5YC8200 (A)2.50NMShuman, cyt-ICL3, 3.39
5ZK3199 (A)2.60QNBhuman, cyt-ICL3, 3.39
5ZK8198 (A)3.00NMShuman, cyt-ICL3
5ZKB200 (A)2.95AF-DX 384human, cyt-ICL3, 3.39
5ZKC200 (A)2.30NMShuman, cyt-ICL3, 3.39
M3 muscarinic4DAJ197 (A)3.40tiotropiumrat, T4L
197 (B)3.40tiotropiumrat, T4L
197 (C)3.40tiotropiumrat, T4L
198 (D)3.40tiotropiumrat, T4L
4U14200 (A)3.57tiotropiumrat, T4L
4U15200 (A)2.80tiotropiumrat, T4L
200 (B)2.80tiotropiumrat, T4L
4U16200 (A)3.70NMSrat, T4L
200 (B)3.70NMSrat, T4L
5ZHP200 (A)3.106o (BS46)rat, T4L, 3.39
200 (B)3.106o (BS46)rat, T4L, 3.39
M4 muscarinic5DSG198 (A)2.60tiotropiumhuman, T4L
200 (B)2.60tiotropiumhuman, T4L
6KP6200 (A)3.00nonehuman, GlgA, 4 mutated
M5 muscarinic6ol9200 (A)2.54tiotropiumhuman, T4L, 3.39
serotonin HT1B5V54200 (A)3.90methiothepinhuman, cyt-ICL3, 3.41
200 (B)3.90methiothepinhuman, cyt-ICL3, 3.41
serotonin HT2A6A93200 (A)3.00risperidonehuman,cyt-ICL3,3.49/3.41
200 (B)3.00risperidonehuman,cyt-ICL3,3.49/3.41
6A94200 (A)2.90zotepinehuman,cyt-ICL3,3.49/3.41
200 (B)2.90zotepinehuman,cyt-ICL3,3.49/3.41
6WH4200 (A)3.4089Fhuman,cyt-ICL3,5.51/7.44
200 (B)3.4089Fhuman,cyt-ICL3,5.51/7.44
200 (C)3.4089Fhuman,cyt-ICL3,5.51/7.44
serotonin HT2C6BQH200 (A)2.70ritanserinhuman,cyt-ICL3,7.45
S1P13V2W200 (A)3.35ML056human, T4L
3V2Y200 (A)2.80ML056human, T4L
LPA14Z34200 (A)3.00ONO-9780307human,cyt-ICL3
4Z35200 (A)2.90ONO-9910539human,cyt-ICL3
4Z36200 (A)2.90ONO-3080573human,cyt-ICL3,5.37/6.59
LPA65XSZ200 (A)3.20nonezebrafish, T4L
Melanocortin-46W25200 (A)2.75SHU9119human, 5 mutated, GlgA
kappa opioid4DJH200 (A)2.90JDTichuman, 1 mutated(3.29), T4L
200 (B)2.90JDTichuman, 1 mutated(3.29), T4L
6VI4200 (A)3.30JDTichuman, 1 mutated(3.29), Nb
200 (B)3.30JDTichuman, 1 mutated(3.29), Nb
mu opioid4DKL200 (A)2.80beta-FNAmouse, T4L
N/OFQ opioid4EA3200 (A)3.01ONNhuman, cyt
200 (B)3.01ONNhuman, cyt
5DHG200 (A)3.00C-35human, cyt
200 (B)3.00C-35human, cyt
5DHH200 (A)3.00SB-612111human, cyt
200 (B)3.00SB-612111human, cyt
delta opioid4EJ4200 (A)3.40naltrindolemouse, T4L
4N6H200 (A)1.80naltrindolehuman, cyt
4RWA198 (A)3.28DIPP-NH2human, cyt
199 (B)3.28DIPP-NH2human, cyt
4RWD200 (A)2.70DIPP-NH2human, cyt, xfel
200 (B)2.70DIPP-NH2human, cyt, xfel
PAR13VW7200 (A)2.20vorapaxarhuman, T4L
PAR25NDD200 (A)2.80AZ8838human,N-T4L,cyt
5NDZ200 (A)3.60AZ3451human,N-T4L,cyt
5NJ6200 (A)4.00invisiblehuman,cyt,Ab
Leukotriene B45X33200 (A)3.70BIIL260pig,T4L
Cys Leukotriene16RZ4200 (A)2.70pranlukasthuman, cyt-ICL3
6RZ5200 (A)2.53zafirlukasthuman, cyt-ICL3
200 (B)2.53zafirlukasthuman, cyt-ICL3
Cys Leukotriene26RZ6200 (A)2.43ONO-2570366human, cyt-ICL3, 3 mutated
6RZ7200 (A)2.43ONO-2570366human, cyt-ICL3, 3 mutated
6RZ8200 (A)2.70ONO-2080365human, cyt-ICL3, 3 mutated
6RZ9200 (A)2.73ONO-2770372human, cyt-ICL3, 3 mutated
Prostaglandin D26D26200 (A)2.80fevipipranthuman, T4L
6D27200 (A)2.74CAY10471human, T4L
Prostaglandin E25YHL200 (A)4.20ONO-AE3-208-Brhuman, Ab, 2 mutated
5YWY200 (A)3.20ONO-AE3-208human, Ab, 2 mutated
thromboxane A26IIU200 (A)2.50ramatrobanhuman, cyt, rub
6IIV200 (A)3.00daltrobanhuman, cyt, rub
P2Y124NTJ199 (A)2.62AZD1283human, cyt-ICL3, 7.49
P2Y14XNV200 (A)2.20BPTUhuman, rub, 7.49
4XNW200 (A)2.70MRS2500human, rub, 7.49
200 (C)2.70MRS2500human, rub, 7.49
succinate6IBB198 (A)2.12nonerat, Nb
198 (C)2.12nonerat, Nb
6RNK198 (A)1.94NF-56-EJ40rat, Nb, 7.32
6Z10198 (A)2.27Q4Trat, Nb, 7.32
OX1 orexin4ZJC200 (A)2.83SB-674042human, GlgA, 6.56
4ZJ8200 (A)2.75suvorexanthuman, GlgA, 6.56
6TO7200 (A)2.26suvorexanthuman, 5 mutated
200 (B)2.26suvorexanthuman, 5 mutated
6TOD200 (A)2.11EMPAhuman, 6 mutated
200 (B)2.11EMPAhuman, 6 mutated
6TOS200 (A)2.13GSK1059865human, 5 mutated
200 (B)2.13GSK1059865human, 5 mutated
6TOT200 (A)2.22lemborexanthuman, 5 mutated
200 (B)2.22lemborexanthuman, 5 mutated
6TP3200 (A)3.04daridorexanthuman, 5 mutated
200 (B)3.04daridorexanthuman, 5 mutated
6TP4200 (A)3.01ACT-462206human, 5 mutated
200 (B)3.01invisiblehuman, 5 mutated
6TP6200 (A)2.34filorexanthuman, 5 mutated
200 (B)2.34filorexanthuman, 5 mutated
6TQ4200 (A)2.30Compound 16human, 5 mutated
200 (B)2.30Compound 16human, 5 mutated
6TQ6200 (A)2.55Compound 14human, 5 mutated
200 (B)2.55Compound 14human, 5 mutated
6TQ7200 (A)2.66SB-334867human, 5 mutated
200 (B)2.66SB-334867human, 5 mutated
6TQ9200 (A)2.65SB-408124human, 5 mutated
200 (B)2.65SB-408124human, 5 mutated
6V9S200 (A)3.50JH112human, 2 mutated, GlgA
OX2 orexin4S0V200 (A)2.50suvorexanthuman, GlgA
5WQC200 (A)1.96EMPAhuman, GlgA
5WS3200 (A)2.30EMPAhuman, GlgA, xfel
6TPG200 (A)2.74EMPAhuman, GlgA, 9 mutated
6TPJ200 (A)2.74suvorexanthuman, GlgA, 9 mutated
200 (B)2.74suvorexanthuman, GlgA, 9 mutated
6TPN200 (A)2.61HTL6641human, GlgA, 9 mutated
ghrelin6KO5200 (A)3.308QXhuman, cyt, Ab, 3.39
AT1 angiotensin4YAY199 (A)2.90ZD7155human, cyt, xfel
4ZUD199 (A)2.80Olmesartanhuman, cyt
CB1 cannabinoid5TGZ200 (A)2.80AM6538human, flavo, 3 mutated
5U09200 (A)2.60taranabanthuman, GlgA, 3.46
6KQI200 (A)3.25ORG27569human, GlgA, 5 mutated
CB2 cannabinoid5ZTY200 (A)2.80AM10257human, T4L, 4 mutated
PAF5ZKP194 (A)2.81SR 27417human, flavo, 4 mutated
5ZKQ200 (A)2.90ABT-491human, T4L, 4 mutated
200 (B)2.90ABT-491human, T4L, 4 mutated
ETB endothelin5GLI200 (A)2.50nonehuman, T4L, 4 mutated
5X93200 (A)2.20K-8794human, T4L, 4 mutated
5XPR200 (A)3.60bosentanhuman, T4L, 3 mutated
6K1Q200 (A)2.70IRL2500human, T4L, 3 mutated
gonadotropin-releasing hormone7BR3200 (A)2.79elagolixhuman, GlgA, 3.39
neuropeptide Y Y15ZBH200 (A)3.00BMS-193885human, T4L, 3.41
5ZBQ200 (A)2.70UR-MK299human, T4L, 3.41
tachykinin NK16E59200 (A)3.40L760735human, GlgA
6HLL200 (A)3.27CP-99,994human, T4L, 5 mutated
6HLO200 (A)2.40Aprepitanthuman, T4L, 5 mutated
6HLP200 (A)2.20Netupitanthuman, T4L, 5 mutated
6J20200 (A)2.70Aprepitanthuman, T4L, 3 mutated
6J21200 (A)3.20Aprepitanthuman, T4L, 4 mutated
oxytocin6TPK199 (A)3.20retosibanhuman, GlgA, 5 mutated
smoothened4JKV199 (A)2.45LY2940680human, cyt
199 (B)2.45LY2940680human, cyt
4O9R199 (A)2.45cyclopaminehuman, cyt-ICL3, xfel
4N4W200 (A)2.80SANT-1human, cyt
4QIM200 (A)2.61ANTA XVhuman, cyt-ICL3
5L7D200 (B)3.20nonehuman, cyt-ICL3, 3.40
200 (B)3.20nonehuman, cyt-ICL3, 3.40
5L7I198 (A)3.30Vismodegibhuman, cyt-ICL3, 3.40
200 (B)3.30Vismodegibhuman, cyt-ICL3, 3.40
5V56200 (A)2.90TC114human, flabo, xfel
200 (B)2.90TC114human, flabo, xfel
5V57200 (A)3.00TC114human, flabo
200 (B)3.00TC114human, flabo
Frizzled 46BD4200 (A)2.40nonehuman, rub,2 mutated
corticotropin-4K5Y194 (A)2.98CP-376395human, T4L-ICL2,9 mutated
releasing factor188 (B)2.98CP-376395human, T4L-ICL2,9 mutated
200 (C)2.98CP-376395human, T4L-ICL2,9 mutated
4Z9G200 (A)3.18CP-376395human, T4L-ICL2,9 mutated
196 (B)3.18CP-376395human, T4L-ICL2,9 mutated
188 (C)3.18CP-376395human, T4L-ICL2,9 mutated
glucagon4L6R199 (A)3.40invisiblehuman, cyt
5EE7197 (A)2.50MK-0893(allost)human, T4L-ICL2,10 mutated
5XEZ200 (A)3.00NNC0640human,T4L-ICL2,Ab,xfel,10 mutated
200 (B)3.00NNC0640human,T4L-ICL2,Ab,xfel,10 mutated
5XF1200 (A)3.19NNC0640human,T4L-ICL2,Ab,10 mutated
200 (B)3.19NNC0640human,T4L-ICL2,Ab,10 mutated
GLP1R5VEW195 (A)2.70PF-06372222human
194 (B)2.70PF-06372222human
5VEX195 (A)3.00NNC0640human
195 (B)3.00NNC0640human
6LN2200 (A)3.2097Yhuman, Ab, 10 mutated
mGluR14OR2196 (A)2.80FITMhuman, cyt
196 (B)2.80FITMhuman, cyt
mGluR54OO9196 (A)2.60mavogluranthuman, T4L-ICL2, 5 mutated
5CGC196 (A)3.1051Dhuman, T4L-ICL2, 5 mutated
5CGD196 (A)2.6051Ehuman, T4L-ICL2, 5 mutated
6FFH196 (A)2.65Fenobamhuman, T4L-ICL2, 5 mutated
6FFI196 (A)2.20MMPEPhuman, T4L-ICL2, 5 mutated