"Inactivated"

Currently uploaded 7TM coordinates are shown in red.

G Protein-Coupled Receptors (inactivated)

antagonist or inverse agonist bound or ligand free

The count for "mutated" in the remarks is of 200 residue 7TM region only.

Abbreviations
reso: resolution (from PDB)
Ab: antibody bound
T4L: ICL3 replaced with T4 lysozyme
T4L-N: T4 lysozyme N-terminally fuzed
T4L-ICL2: ICL2 replaced with T4 lysozyme
cyt: N-term replaced with mutated apocytochrome b562
cyt-ICL3: ICL3 replaced with mutated apocytochrome b562
rub: ICL3 replaced with rubredoxin
flabo: ICL3 replaced with flabodoxin
GlgA-ICL3: ICL3 replaced with catalytic domain of glycogen synthase GlgA
xfel: x-ray free electron laser
IMIS: in meso in situ
ortho: orthosteric ligand

receptorPDB7TMresoligandremarks
rhodopsin1GZM200 (A)2.6511-cis-retinalbovine
200 (B)2.6511-cis-retinalbovine
1U19200 (A)2.2011-cis-retinalbovine
200 (B)2.2011-cis-retinalbovine
2I35200 (A)3.8011-cis-retinalbovine
2I36200 (A)4.1011-cis-retinalbovine
196 (B)4.1011-cis-retinalbovine
200 (C)4.1011-cis-retinalbovine
2J4Y200 (A)3.4011-cis-retinalbovine
200 (B)3.4011-cis-retinalbovine
2PED200 (A)2.959-cis-retinalbovine
200 (B)2.959-cis-retinalbovine
2Z73200 (A)2.5011-cis-retinalsquid
200 (B)2.5011-cis-retinalsquid
2ZIY200 (A)3.7011-cis-retinalsquid
3AYN200 (A)2.709-cis-retinalsquid
200 (B)2.709-cis-retinalsquid
beta2 adrenergic2RH1200 (A)2.40carazorolhuman, T4L
2R4R161 (A)3.40invisiblehuman, Ab
2R4S161 (A)3.40invisiblehuman, Ab
3D4S200 (A)2.80timololhuman, 1 mutated(3.41), T4L
3KJ6167 (A)3.40invisiblehuman, Ab, methylated
3NY8200 (A)2.84ICI 118551human, 1 mutated(3.41), T4L
3NY9200 (A)2.84JSZhuman, 1 mutated(3.41), T4L
3NYA200 (A)3.16alprenololhuman, 1 mutated(3.41), T4L
4GBR200 (A)3.99carazorolhuman, 1 mutated(2.67), T4L-N
5D5A200 (A)2.48carazorolhuman, T4L, IMIS
5D5B200 (A)3.80carazorolhuman, T4L
5JQH200 (A)3.20carazorolhuman,2.67,T4L-N,Nb
200 (B)3.20carazorolhuman,2.67,T4L-N,Nb
beta1 adrenergic2VT4200 (A)2.70cyanopindololturkey,6 mutated,TM1 bent
200 (B)2.70cyanopindololturkey,6 mutated
200 (C)2.70cyanopindololturkey,6 mutated
200 (D)2.70cyanopindololturkey,6 mutated,TM1 bent
2YCW200 (A)3.00carazorolturkey,6 mutated,TM6 bent
200 (B)3.00carazorolturkey,6 mutated
2YCY200 (A)3.15cyanopindololturkey,6 mutated,TM1 bent
200 (B)3.15cyanopindololturkey,6 mutated
2YCX200 (A)3.25cyanopindololturkey,6 mutated,TM6 bent
200 (B)3.25cyanopindololturkey,6 mutated,TM6 bent
2YCZ200 (A)3.65iodocyanopindololturkey,6 mutated
200 (B)3.65iodocyanopindololturkey,6 mutated,TM6 bent
4AMJ200 (A)2.30carvedilolturkey,6 mutated
200 (B)2.30carvedilolturkey,6 mutated
4GPO200 (A)3.50noneturkey,6 mutated
200 (B)3.50noneturkey,6 mutated
4BVN200 (A)2.10cyanopindololturkey,9 mutated
3ZPQ200 (A)2.80indole19turkey,6 mutated
200 (B)2.80indole19turkey,6 mutated
3ZPR200 (A)2.70quinoline20turkey,6 mutated
200 (B)2.70quinoline20turkey,6 mutated
5A8E200 (A)2.407-Me-cyanopindololturkey,9 mutated
adenosine A2A3EML200 (A)2.60ZM241385human, T4L
3PWH200 (A)3.30ZM241385human, 8 mutated
3REY200 (A)3.31XAChuman, 8 mutated
3RFM200 (A)3.60caffeinehuman, 8 mutated
3VG9200 (A)2.70ZM241385human, Ab
3VGA200 (A)3.10ZM241385human, Ab
3UZA200 (A)3.27compound 4Ghuman, 8 mutated
3UZC200 (A)3.34compound 4Ehuman, 8 mutated
4EIY200 (A)1.80ZM241385human, cyt-ICL3
5IU4200 (A)1.72ZM241385human,cyt-ICL3,8 mutated
5IU7200 (A)1.90compound 12chuman,cyt-ICL3,8 mutated
5IU8200 (A)2.00compound 12fhuman,cyt-ICL3,8 mutated
5IUA200 (A)2.20compound 12bhuman,cyt-ICL3,8 mutated
5IUB200 (A)2.10compound 12xhuman,cyt-ICL3,8 mutated
adenosine A15UEN200 (A)3.20DU172human,cyt-ICL3
200 (B)3.20DU172human,cyt-ICL3
CXCR4 chemokine3ODU200 (A)2.50It1thuman, T4L
200 (B)2.50It1thuman, T4L
3OE8200 (A)3.10It1thuman, T4L
200 (B)3.10It1thuman, T4L
200 (C)3.10It1thuman, T4L
3OE9196 (A)3.10It1thuman, T4L
196 (B)3.10It1thuman, T4L
3OE6198 (A)3.20It1thuman, T4L
3OE0199 (A)2.90CVX15 peptidehuman, T4L
4RWS199 (A)3.10vMIP-IIhuman,1 mutated(6.36), T4L
CCR2 chemokine5T1A200 (A)2.81BMS-681human,T4L,+ortho,8 mutated
CCR5 chemokine4MBS200 (A)2.70maravirochuman,rub,4.60,6.33
200 (B)2.70maravirochuman,rub,4.60,6.33
CCR9 chemokine5LWE196 (A)2.80vercirnon(ic side)human,5 mutated
197 (B)2.80vercirnon(ic side)human,5 mutated
dopamine D33PBL200 (A)2.89eticlopridehuman, T4L
200 (B)2.89eticlopridehuman, T4L
histamine H13RZE200 (A)3.10doxepinhuman, T4L
M1 muscarinic5CXV200 (A)2.70tiotropiumhuman, T4L
M2 muscarinic3UON200 (A)3.00QNBhuman, T4L
M3 muscarinic4DAJ197 (A)3.40tiotropiumrat, T4L
197 (B)3.40tiotropiumrat, T4L
197 (C)3.40tiotropiumrat, T4L
198 (D)3.40tiotropiumrat, T4L
4U14200 (A)3.57tiotropiumrat, T4L
4U15200 (A)2.80tiotropiumrat, T4L
200 (B)2.80tiotropiumrat, T4L
4U16200 (A)3.70NMSrat, T4L
200 (B)3.70NMSrat, T4L
M4 muscarinic5DSG198 (A)2.60tiotropiumhuman, T4L
200 (B)2.60tiotropiumhuman, T4L
S1P13V2W200 (A)3.35ML056human, T4L
3V2Y200 (A)2.80ML056human, T4L
LPA14Z34200 (A)3.00ONO-9780307human,cyt-ICL3
4Z35200 (A)2.90ONO-9910539human,cyt-ICL3
4Z36200 (A)2.90ONO-3080573human,cyt-ICL3,5.37/6.59
kappa opioid4DJH200 (A)2.90JDTichuman, 1 mutated(3.29), T4L
200 (B)2.90JDTichuman, 1 mutated(3.29), T4L
mu opioid4DKL200 (A)2.80beta-FNAmouse, T4L
N/OFQ opioid4EA3200 (A)3.01ONNhuman, cyt
200 (B)3.01ONNhuman, cyt
5DHG200 (A)3.00C-35human, cyt
200 (B)3.00C-35human, cyt
5DHH200 (A)3.00SB-612111human, cyt
200 (B)3.00SB-612111human, cyt
delta opioid4EJ4200 (A)3.40naltrindolemouse, T4L
4N6H200 (A)1.80naltrindolehuman, cyt
4RWD200 (A)2.70DIPP-NH2human, cyt, xfel
200 (B)2.70DIPP-NH2human, cyt, xfel
protease-activated3VW7200 (A)2.20vorapaxarhuman, T4L
P2Y124NTJ199 (A)2.62AZD1283human, cyt-ICL3, 7.49
P2Y14XNV200 (A)2.20BPTUhuman, rub, 7.49
4XNW200 (A)2.70MRS2500human, rub, 7.49
200 (C)2.70MRS2500human, rub, 7.49
OX2 orexin4S0V200 (A)2.50suvorexanthuman, GlgA-ICL3
AT1 angiotensin4YAY199 (A)2.90ZD7155human, cyt, xfel
4ZUD199 (A)2.80Olmesartanhuman, cyt
CB1 cannabinoid5TGZ200 (A)2.80AM6538human, flavo, 3 mutated
5U09200 (A)2.60taranabanthuman, GlgA, 3.46
ETB endothelin5GLI200 (A)2.50nonehuman, T4L
smoothened4JKV199 (A)2.45LY2940680human, cyt
199 (B)2.45LY2940680human, cyt
4O9R199 (A)2.45cyclopaminehuman, cyt-ICL3, xfel
4N4W200 (A)2.80SANT-1human, cyt
4QIM200 (A)2.61ANTA XVhuman, cyt-ICL3
5L7D200 (B)3.20nonehuman, cyt-ICL3, 3.40
200 (B)3.20nonehuman, cyt-ICL3, 3.40
5L7I198 (A)3.30Vismodegibhuman, cyt-ICL3, 3.40
200 (B)3.30Vismodegibhuman, cyt-ICL3, 3.40
corticotropin-4K5Y194 (A)2.98CP-376395human, T4L-ICL2,9 mutated
releasing factor188 (B)2.98CP-376395human, T4L-ICL2,9 mutated
200 (C)2.98CP-376395human, T4L-ICL2,9 mutated
glucagon4L6R199 (A)3.40invisiblehuman, cyt
5EE7197 (A)2.50MK-0893(allost)human, T4L-ICL2,8 mutated
mGluR14OR2196 (A)2.80FITMhuman, cyt
196 (B)2.80FITMhuman, cyt
mGluR54OO9196 (A)2.60mavogluranthuman, T4L-ICL2, 5 mutated
5CGC196 (A)3.1051Dhuman, T4L-ICL2, 5 mutated
5CGD196 (A)2.6051Ehuman, T4L-ICL2, 5 mutated